Award details

A high-resolution ToF-SIMS chemical microscope for biology

Reference	BBS/B/03920
Principal Investigator / Supervisor	Professor John Vickerman
Co-Investigators / Co-Supervisors	Professor Royston Goodacre, Professor Dean Jackson, Professor Douglas Kell, Professor Nicholas Lockyer
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	422,077
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/03/2008
Duration	44 months

Abstract

The existing successful development of a ToF-SIMS chemical microscope will be enhanced by the incorporation of a new buckminsterfullerene based ion beam system delivering for the first time both very high ion yields and 100nm spatial resolution. This instrument will be used with FT-IR and Raman spectroscopy to probe spatially resolved (2D and 3D) chemistry in four cell and microbiology projects. These are all multicomponent systems. The resulting mass spectra will be complex. An integral aspect of the project will therefore be to develop evolutionary computing methods not only to interpret the spectra, but also for the first time to deliver biochemically understandable images of the systems studied.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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