Award details

Comparative proteomics of the Apicomplexa: evolutionary perspectives and functional analyses of invasion organelles

Reference	BBS/B/03858
Principal Investigator / Supervisor	Professor Robert Sinden
Co-Investigators / Co-Supervisors	Mr John Raine
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	360,291
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	31/08/2007
Duration	36 months

Abstract

Apicomplexans are the most important parasites of man and livestock. The proposal integrates four research teams with complementary skills in a fundamental study to a) Overview the biomolecular organisation and molecular evolution of apicomplexans through comparative proteomics of purified invasive stages of Cryptosporidium, Eimeria, Plasmodium and Toxoplasma. b) Analyse the proteomes of secretory organelles and with carefully selected gene knockout, protein tagging/localisation, and protein co-precipitation studies further elucidate the role of these organelles in host cell recognition and invasion. The data will be of fundamental and broad specific value and provide a rational foundation for the development of new therapeutic targets. (Joint with BBS/B/03807 and BBS/B/03742)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/03742 Comparative proteomics of the Apicomplexa: evolutionary perspectives and functional analyses of invasion organelles

BBS/B/03807 Comparative proteomics of the Apicomplexa: evolutionary perspectives and functional analyses of invasion organelles

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