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The functional role and regulation of the FOXO forkhead family of transcription factors
Reference
BBS/B/03785
Principal Investigator / Supervisor
Professor Eric Lam
Co-Investigators /
Co-Supervisors
Dr Silvia Fernandez de Mattos
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
195,981
Status
Completed
Type
Research Grant
Start date
31/08/2004
End date
30/08/2007
Duration
36 months
Abstract
The Forkhead/winged helix family of transcription factors are the recently discovered and least studied components of the PI3-K/PKB signalling pathway. Members of the FOXO subgroup of the Forkhead proteins, including FOXO1a (FKHR), FOXO3a (FKHRL1) and FOXO4 (AFX), are downstream targets of the PKB(Akt). The aim of this proposal is to examine the functional roles of the FOXO proteins in cell cycle progression, cell survival and development, and to define mechanisms by which FOXO expression and activity are regulated. As the FOXO proteins can exert their functions dependent as well as independent of nuclear receptors, we also plan to investigate the effect of nuclear receptors on FOXO functions. This project will identify key signalling events and intermediates essential for mediating the proliferative, apoptotic and differentiation functions of the FOXO proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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