Award details

Analysis of handling of apoptotic cells by DCs derived from normal and autoimmune prone mice

Reference	BBS/B/0370X
Principal Investigator / Supervisor	Professor Anne Cooke
Co-Investigators / Co-Supervisors	Dr Tina Rich
Institution	University of Cambridge
Department	Pathology
Funding type	Research
Value (£)	187,935
Status	Completed
Type	Research Grant
Start date	12/07/2004
End date	11/07/2007
Duration	36 months

Abstract

Cells can die by necrosis or apoptosis. While the former mode of death can lead to inflammation the latter is thought to be tolerated by the immune system. It has been suggested that defective clearance of apoptotic bodies breaks this tolerance. This hypothesis can be tested using cells that are predestined to drive an inflammatory response. We have designed a series of experiments to investigate how the normal and inflammatory response to apoptotic cells develops, in terms of defects in both the effector and target cells. These data can be applied to all fundamental processes that rely on apoptotic clearance to maintain normal cellular homeoastasis. As such they are relevant to basic developmental disorders, autoimmunity, persistent viral infection and neurodegeneration.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search