Award details

An investigation of TSE resistance mechanisms by genetic analysis of PrP binding protein genes

Reference	BBS/B/03688/2
Principal Investigator / Supervisor	Dr Wilfred Goldmann
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	40,910
Status	Completed
Type	Research Grant
Start date	01/09/2007
End date	29/02/2008
Duration	6 months

Abstract

The PrP protein allotypes are crucial modulators of TSE pathogenesis. Amino acid changes in PrP can mean the difference between susceptibility and resistance but the mechanism though which these effects are enacted is not understood. PrP-binding protein (PrPbp) genes, ie. NCAM or laminin receptor are prime candidates to explore the causal relationship between PrP alleles and phenotypes such as neuronal cell death. We propose to investigate PrPbps in our well-understood sheep scrapie models, by initiating an analysis of their gene sequences, polymorphisms and expression patterns in scrapie-relevant tissues. Co- immunoprecipitations will provide detailed analysis of the molecular interaction between allotypes of PrP and its protein ligands.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/03688 An investigation of TSE resistance mechanisms by genetic analysis of PrP binding protein genes

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search