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An investigation of TSE resistance mechanisms by genetic analysis of PrP binding protein genes

ReferenceBBS/B/03688
Principal Investigator / Supervisor Dr Wilfred Goldmann
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentNeuropathogenesis Unit
Funding typeResearch
Value (£) 190,647
StatusCompleted
TypeResearch Grant
Start date 01/10/2004
End date 31/03/2007
Duration30 months

Abstract

The PrP protein allotypes are crucial modulators of TSE pathogenesis. Amino acid changes in PrP can mean the difference between susceptibility and resistance but the mechanism though which these effects are enacted is not understood. PrP-binding protein (PrPbp) genes, ie. NCAM or laminin receptor are prime candidates to explore the causal relationship between PrP alleles and phenotypes such as neuronal cell death. We propose to investigate PrPbps in our well-understood sheep scrapie models, by initiating an analysis of their gene sequences, polymorphisms and expression patterns in scrapie-relevant tissues. Co-immunoprecipitations will provide detailed analysis of the molecular interaction between allotypes of PrP and its protein ligands.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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