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Regulation of cellular internal ribsome entry segment (IRES)
Reference
BBS/B/03556
Principal Investigator / Supervisor
Professor Anne Willis
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
199,006
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
31/07/2007
Duration
37 months
Abstract
Two major mechanisms are used to initiate translation in eukaryotic cells cap-dependent scanning and internal ribosome entry. The latter process requires the formation of a complex structural element in the 5-prime untranslated region of the mRNA and this structured RNA in the presence of trans-acting factors (ITAFs) recruits the ribosome. Internal ribosome entry occurs when the cap-dependent scanning mechanism of translation initiation is reduced e.g. following cell stress such as heat shock or during apoptosis. The cellular pathways that regulate internal ribosome entry by modifying, for example, the levels, phosphorylation states, or subcellular location of ITAFs have not been determined. The aims of this proposal are to investigate how ITAFs are regulated and how this selects for internal ribosome entry rather than cap-dependent scanning.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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