Award details

Structure and function of myosin 9

Reference	BBS/B/03432
Principal Investigator / Supervisor	Professor Michelle Peckham
Co-Investigators / Co-Supervisors	Professor Peter Knight
Institution	University of Leeds
Department	Institute of Membrane & Systems Biology
Funding type	Research
Value (£)	313,627
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	31/08/2007
Duration	42 months

Abstract

Myosins are a diverse group of motor proteins found in almost every cell, in both plant and animal kingdoms. Many of them have only been identified from DNA sequence analysis, and little is known about their cellular functions. Every myosin is thought to contain a motor domain that interacts with actin to generate movement and a tail domain that couples this movement to a cellular process. Both tail and motor are probably adapted for this process. In this project, we will focus on myosin 9, which is implicated in cell signalling events that involve the small G-protein rho. We can now purify this myosin, so our aim is to determine its structure and function using a range of complementary biochemical and biophysical techniques.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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