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Contribution of conserved features of the multisubunit RNA polymerase (RNAP) to transcription initiation

Reference	BBS/B/03351
Principal Investigator / Supervisor	Professor Martin Buck
Co-Investigators / Co-Supervisors	Professor Sivaramesh Wigneshweraraj
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	200,636
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/06/2007
Duration	36 months

Abstract

The recent crystallographic structures of multisubunit bacterial and eukaryotic RNAPs, including structures and models of elongation complexes, provide an opportunity to study this central enzyme of gene expression in mechanistic detail. Multisubunit RNAPs share a strikingly similar structure, suggesting that insights into regulatory regions, domains and even individual residues will be of universal significance. Here we propose to study the contribution of several conserved features of the Escherichia coli RNAP to the process of DNA opening and transcription initiation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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