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Functional genomic analysis of pasteurellaceae Adhesins

Reference	BBS/B/03238
Principal Investigator / Supervisor	Professor Brian Henderson
Co-Investigators / Co-Supervisors	Dr Sean Nair, Professor Andrew Rycroft, Professor John Ward
Institution	University College London
Department	Eastman Dental Institute
Funding type	Research
Value (£)	185,651
Status	Completed
Type	Research Grant
Start date	16/08/2004
End date	15/08/2007
Duration	36 months

Abstract

Whilst we understand much about the interactions of enteropathogens with host cells/matrices, much less is known about such interactions in members of the Pasteurellaceae, bacteria generally found in the oropharynx and capable of causing disease in both man and animals. Genome analysis has revealed significant conservation among shared Pasteurellaceae genes, but the different disease states caused by these bacteria signifies that different networks of virulence determinants are utilised by each of these organisms. We propose to use a functional genomic methodology, phage display, to identify the network of genes utilised by members of the Pasteurellaceae to interact with host cells and their extracellular matrices.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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