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Modulation of antigen-presenting cell function by naturally occurring regulatory T cells

Reference	BBS/B/03181
Principal Investigator / Supervisor	Professor Leonie Taams
Co-Investigators / Co-Supervisors
Institution	King's College London
Department	Immunobiology
Funding type	Research
Value (£)	231,464
Status	Completed
Type	Research Grant
Start date	15/04/2004
End date	14/11/2007
Duration	43 months

Abstract

Immune regulation is important to prevent chronic inflammation or autoimmunity. CD4+CD25+ regulatory T cells (Tregs) play a pivotal role in this process. The suppressive effects of Tregs on T cells have been amply demonstrated but not much is known about the effects on antigen-presenting cells (APC). In this study we will determine how Tregs affect the function of different APC subsets (dendritic cells, monocytes, macrophages). Using co-culture assays we will assess the effects on phagocytosis, oxidative burst, cytokine profile and T cell stimulation, and investigate the mechanism behind suppression. The results will clarify how APC function might be regulated in vivo and how this could be manipulated in order to divert an immune response.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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