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Cellular defences against reactive aldehyde toxicity
Reference
BBS/B/03009
Principal Investigator / Supervisor
Professor Christopher Grant
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
216,211
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
30/06/2007
Duration
36 months
Abstract
All organisms encounter reactive oxygen species (ROS) during the course of normal aerobic metabolism or following exposure to radical generating compounds. Left unchecked, these reactive species can damage various cellular macromolecules eventually leading to cell death. As a result of lipid oxidation, a variety of lipid hydroperoxides are formed, the aldehyde breakdown products of which, may well be as toxic as the ROS themselves. The aim of this study is to use the yeast Saccharomyces cerevisiae to characterise the molecular basis of the toxicity caused by reactive aldehydes. In particular, we will characterise the cellular defence systems which protect against the damaging effects of reactive aldehydes.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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