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Nitric oxide reactive oxygen species their interplay and detoxification in Neisseria meningitidis
Reference
BBS/B/02835
Principal Investigator / Supervisor
Professor James Moir
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
171,544
Status
Completed
Type
Research Grant
Start date
19/07/2004
End date
18/01/2008
Duration
42 months
Abstract
The human pathogen Neisseria meningitidis possesses detoxification systems for nitric oxide (NO) and superoxide (02-) which contribute to the survival of the organism in models of human colonisation and infection. We will test the extent to which combined nitrosative and oxidative stress is mediated via peroxynitrite; and we will determine the roles of NO and O2 detoxifying enzymes in controlling this stress and controlling the accumulation of NO and reactive oxygen species in the cell. Also, we will determine the effect of 02 limited growth and reductive nitrogen metabolism on protein expression in pure culture, and its relevance to expression in vivo. The effect of NO reductase expression on sensitivity to NO and survival in macrophages will be assessed and we will also determine the functions of putative peroxynitrite reductases (GpxA and AhpC) and a catalase (KatA).
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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