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Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions

Reference	BBS/B/02649
Principal Investigator / Supervisor	Professor Jeremy Turnbull
Co-Investigators / Co-Supervisors	Professor David Fernig, Dr Andrew Powell, Dr Edwin Yates
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	274,657
Status	Completed
Type	Research Grant
Start date	01/02/2004
End date	31/01/2007
Duration	36 months

Abstract

We propose to apply and extend a novel array strategy for rapid screening of heparan sulphate (HS) -protein interactions. HS polysaccharides are multifunctional regulators in which specific protein-binding sequences determine selective regulatory properties. These interactions impinge on many biological systems and disease processes. The array strategy provides a powerful new technology for rapid identification of bioactive saccharides. We plan to apply the method for interrogation of the specificity of the interaction of HS with multiple protein ligands, and we will also investigate its application as a glycomics approach for studying tissue HS interactions with relevant biological ligands.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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