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Identifying 'metallomes' and the contributions of copper-trafficking and zinc-buffering in cyanobacteria

Reference	BBS/B/02576
Principal Investigator / Supervisor	Professor Nigel Robinson
Co-Investigators / Co-Supervisors	Dr Andrew Morby, Dr Nicholas Morris
Institution	Newcastle University
Department	Inst for Cell and Molecular Biosciences
Funding type	Research
Value (£)	255,411
Status	Completed
Type	Research Grant
Start date	14/03/2005
End date	13/03/2008
Duration	36 months

Abstract

A very substantial proportion of proteins requires metals; recent estimates are 30 to 50 per cent. Optimal cell function requires the correct metals to locate to the correct proteins. Environmental factors (fluctuations in exogenous metals, oxidative stress) are thought to alter intracellular metal-protein speciation (metallomes) even within a constant proteome. An unusual proteomic approach will identify copper- and zinc-binding proteins. Changes in the protein-distribution of these metals will be analysed in cyanobacteria. We have characterised intracellular copper- and zinc-handling proteins in these organisms and will analyse metallomes in mutants, in response to changes in extracellular metal-concentrations and oxidative stress.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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