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Detection and disposal of misfolded non-glycosylated membrane proteins at the endoplasmic reticulum
Reference
BBS/B/02568
Principal Investigator / Supervisor
Dr Eileithyia Swanton
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
246,360
Status
Completed
Type
Research Grant
Start date
01/09/2004
End date
31/10/2007
Duration
38 months
Abstract
The endoplasmic reticulum (ER) is an important site for the biosynthesis of many cellular proteins. The fidelity of this process is monitored by a quality control system that identifies and eliminates aberrant proteins. Although a significant number of proteins synthesised at the ER are not N-glycosylated, very little is known about mechanisms that underlie glycan-independent quality control. To this end, I have recently begun to study the quality control of non-glycosylated membrane proteins. The research proposed here aims to build on this work by characterising key components involved in the detection and disposal of aberrant non-glycosylated membrane proteins at the ER and identifying additional factors that play a role in this process.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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