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The role of the co-activator protein Ndd 1 p in regulating cell cycle-dependent transcription in S. cerevisiae

Reference	BBS/B/02509
Principal Investigator / Supervisor	Professor Andrew Sharrocks
Co-Investigators / Co-Supervisors	Professor Brian Morgan
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	229,728
Status	Completed
Type	Research Grant
Start date	09/03/2004
End date	08/03/2007
Duration	36 months

Abstract

The Mcm1p-Fkh2p-Ndd1p complex plays a pivotal role in controlling the transcriptional events that drive the late events during the cell cycle in S. cerevisiae. Both the Fkh2p and Ndd1p components of this complex are phosphorylated in a cell cycle-dependent manner by Cdc28p-Clbp complexes. Here we wish to understand how the Mcm1p-Fkh2p-Ndd1p complex activates transcription of its target genes and how these phosphorylation events regulate this process. In particular we will focus on the co-activator Ndd1p and study both how it activates transcription and also its role in downregulation of complex activity. Overall, we aim to discover how tight temporal control of transcriptional events in the cell cycle is elicited at the molecular level.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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