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New immobilised ribosome systems for the use in bionanotechnology and pharmaceutical screening
Reference
BBS/B/02436
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
204,626
Status
Completed
Type
Research Grant
Start date
01/02/2004
End date
31/01/2007
Duration
36 months
Abstract
This work will generate new enabling technology that will benefit several types of academic and pharmaceutical research activity. 1) It will provide novel immobilised systems for use in a new range of high-throughput ligand screening strategies targeted at different steps of the translation process. 2) The immobilised ribosomes will also be ideal for single molecule imaging and force studies of prokaryotic and eukaryotic ribosome functions. 3) Comparative analysis of prokaryotic and eukaryotic (yeast) ribosome functions using these techniques will be possible, and the immobilisation procedure (and thus research strategies) will be readily extendable to mammalian ribosomes.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
Industrial Partnership Award (IPA)
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