Award details

The supramolecular assembly of collagen VIII

Reference	BBS/B/02428
Principal Investigator / Supervisor	Professor Cay Kielty
Co-Investigators / Co-Supervisors	Dr Charles Shuttleworth
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	196,834
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/04/2008
Duration	43 months

Abstract

Collagen VIII is a short-chain collagen that forms extracellular hexagonal lattices, and is expressed by vascular and corneal cells. Mutations in alpha2 (VIII) cause corneal endothelial dystrophies. We expressed triple helical collagen VIII and identified a novel 720 kDa tetrahedron assembly. Our aim now is to determine how tetrahedrons form lattices, and structure:function relationships. We will determine how tetrahedrons are stabilised, what interactions drive further assembly, and how assembly influences stability and function. This fundamental biology of collagen VIII is required for understanding its biological roles, vascular tissue engineering applications, and defining genotype-phenotype correlations in corneal endothelial dystrophies.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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