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Determining the roles of ribophorin I during membrane protein synthesis and maturation at the endoplasmic reticulum
Reference
BBS/B/02398
Principal Investigator / Supervisor
Professor Stephen High
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
212,180
Status
Completed
Type
Research Grant
Start date
28/04/2004
End date
27/04/2007
Duration
36 months
Abstract
The N-glycosylation of proteins at the endoplasmic reticulum (ER) is essential for life, and defects in this process are the molecular basis for a number of human diseases. The process of N-glycosylation is catalysed by the oligosaccharyl-transferease (OST), a multi-subunit complex that is resident in the ER. We have discovered a novel and specific association between the ribophorin I subunit of OST, and several newly synthesised membrane proteins. The function of ribophorin I is currently unknown, and we believe that it contributes to both substrate recognition and delivery for the OST, and enforcing quality control over nascent membrane proteins. The aim of this project is to carry out a co-ordinated study that will define the roles of ribophorin I during membrane protein synthesis and establish whether all of these functions relate solely to the action of the OST complex.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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