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Interaction between host and pathogen at the single cell level in vivo: dynamics and determinants of bacterial growth and distribution during Salmonella infection

Reference	BBS/B/02266
Principal Investigator / Supervisor	Dr Pietro Mastroeni
Co-Investigators / Co-Supervisors	Professor Duncan Maskell
Institution	University of Cambridge
Department	Veterinary Medicine
Funding type	Research
Value (£)	413,325
Status	Completed
Type	Research Grant
Start date	01/04/2005
End date	31/03/2008
Duration	36 months

Abstract

The central hypothesis behind the project is that the outcome of a Salmonella infection depends on host-pathogen interactions acting independently at individual cells. Using mutant bacteria, gene-targeted mice and advanced multicolour fluorescence microscopy techniques we shall study: a) how individual bacterial populations distribute in the tissues; b) those host and bacterial factors that regulate interactions between Salmonella and individual host cells; c) whether active evasion of immune responses contributes to Salmonella spread and persistence in the body; d) how vaccine-induced immunity and treatment with various classes of antibiotics affects the growth, spread and persistence of Salmonella in the body at the level of individual cells. This research will provide a new approach to the study of bacterial pathogenesis in vivo.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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