Award details

Role of MKK4 in neuronal death in vivo

Reference	BBS/B/0224X
Principal Investigator / Supervisor	Dr Cathy Tournier
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	312,873
Status	Completed
Type	Research Grant
Start date	16/07/2004
End date	15/07/2007
Duration	36 months

Abstract

The aim of this project is to test the hypothesis that MKK4 is required in vivo for regulating neuronal apoptosis in the brain. A novel genetically modified mouse model in which the mkk4 gene can be conditionally deleted will be used for these studies. The effect of mkk4 ablation on the apoptotic response of primary cultures of neurones following NGF withdrawal or exposure to oxidative stress will be elucidated. To assess the biological significance of these results, the role of MKK4 in the regulation of neuronal death during brain development or associated with ischaemia will be determined. This information will be critical to help develop novel strategies to treat certain human brain diseases associated with abnormal neuronal death.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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