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Development of novel complementation systems for highly deleted adenovirus vectors
Reference
BBS/B/02169
Principal Investigator / Supervisor
Professor Keith Leppard
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
208,548
Status
Completed
Type
Research Grant
Start date
01/06/2004
End date
31/05/2007
Duration
36 months
Abstract
Gene delivery into mammalian cells has huge therapeutic potential. Adenovirus has been modified to carry genes into cells located within tissues of the body but these vectors still have shortcomings that prevent full-scale application in gene therapy. This study addresses the problem of poor persistence of transgenes, due to immune responses to residual viral protein expression from vector DNA sequences, while retaining the key advantages of this virus as a vector. A recent advance in our knowledge about how the expression of adenovirus genes is controlled, coupled with a new strategy to make cells that produce specific proteins of interest will be exploited to produce novel Ad vector systems with improved biological characteristics.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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