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Studies on an evolutionary conserved variant of the glucocorticoid receptor.

Reference	BBS/B/02029
Principal Investigator / Supervisor	Dr Michael Norman
Co-Investigators / Co-Supervisors	Dr Andrea Flynn, Professor Kevin Gaston, Professor Stafford Lightman
Institution	University of Bristol
Department	Physiology and Pharmacology
Funding type	Research
Value (£)	219,817
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

We have found that a splice variant of the glucocorticoid receptor (GR gamma) is evolutionarily conserved and has unique properties. We propose that the additional arginine inserted in the DNA binding domain of GR gamma permits unique protein/protein interactions, so that the variant performs gene regulatory functions that are distinct from those of the classical form (GR alpha). This hypothesis will be tested by analysis of (a) GR gamma expression, (b) the molecular basis for enhanced interactons between GR gamma and STAT transcription factors, and (c) interactions with proteins not previously shown to interact with the GR.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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