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Role of phosphatidylinositol 3-kinases in B cell homeostasis and function

Reference	BBS/B/02010
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	255,208
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

The roles of the 4 type I PI3-K in the PI3K-dependent processes that characterise B cell function are still largely unknown. We have shown P110 delta has an important role in B cell development and function, but have evidence of a role for additional, so far unidentified, p110 subunits. Here we propose to study the role of p110beta, gamma and delta in B cell survival mediated by BlyS, CD40 and CD19 pathways. We will establish 1) if transgenic restoration of Bcl2 expression rescues B cell survival in p110 delta mutants; 2) the requirement for p110 delta in survival versus development of MZ and Follicular B cells 3) the requirement for PI3K in activation of Btk and the processing and presentation of antigen. Defining specific roles for individual PI3-K genes in different biochemical and cellular pathways will have a major impact on our understanding of the molecular mechanisms of these processes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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