Award details

Developing chemical agents for monitoring oxidative stress and inflammatory processes

Reference	BBS/B/01553
Principal Investigator / Supervisor	Professor Corinne Spickett
Co-Investigators / Co-Supervisors	Dr John Reglinski
Institution	University of Strathclyde
Department	Bioscience
Funding type	Research
Value (£)	218,610
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/07/2007
Duration	36 months

Abstract

A new range of transition metal complexes able to sense oxidants are being synthesized as part of a funded Phd project, with the ultimate aim of developing imaging agents able to visualise oxidative stress and inflammation. These complexes change colour and become paramagnetic on oxidation, allowing detection by NMR. This project will characterise the redox properties of these complexes, their interactions with biological reductants and antioxidant enzymes, their toxicity and oxidation by stimulated phagocytic cells. The research will involve spectrophotometric analyses and T1 broadening of water in the NMR spectra. This fundamental research provides the basis for better future diagnosis and therapy of inflammatory diseases.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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