Award details

Inflammatory diseases: development of oxidation-sensitive colloidal carriers for anti-inflammatory drug delivery

Reference	BBS/B/01537
Principal Investigator / Supervisor	Professor Nicola Tirelli
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Manchester Pharmacy School
Funding type	Research
Value (£)	202,639
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	30/11/2007
Duration	39 months

Abstract

A novel drug targeted nanotechnology is proposed to develop the basis of a new approach for the treatment of inflammatory conditions. Polysulfide nanoparticles are oxidation-responsive colloidal carriers; they can be switched by oxidation from hydrophobic to hydrophilic and, with an appropriate molecular design, may completely solubilise. This transition can be coupled with the release of encapsulated hydrophobic molecules. Bearing in mind the occurrence of strongly oxidative conditions in most inflammatory reactions, polysulfide nanoparticles are proposed for inflammation-triggered release of anti-inflammatory drugs. This project aims to characterise the mechanism of their oxidative response and link it to the release kinetics of model drugs and to the possibility of phagocytic uptake by monocytes and macrophages.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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