Award details

E. coli aconitases and post-transcriptional responses to oxidative stress

Reference	BBS/B/01472
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	217,172
Status	Completed
Type	Research Grant
Start date	18/05/2004
End date	17/09/2007
Duration	40 months

Abstract

E. coli aconitases (Acns) are remarkable bifunctional proteins. As well as being key enzymes of the citric acid cycle, under conditions of iron-starvation or oxidative stress they act as post-transcriptional regulators by binding specific transcripts to either, enhance transcript stability, or block translation. The proposal aims to (i) characterise the role of Acns in the post-transcriptional response to oxidative stress by identifying new Acn targets and investigating the contributions made by these new targets towards the management of oxidative stress in E. coli; and (ii) investigate the structure-function relationships in the interactions between Acn and target transcripts.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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