Award details

Role of adrenocorticortophic hormone in regulating fetal testis function

Reference	BBS/B/01359
Principal Investigator / Supervisor	Professor Peter O'Shaughnessy
Co-Investigators / Co-Supervisors	Dr Harry Charlton
Institution	University of Glasgow
Department	Veterinary Cell Sciences
Funding type	Research
Value (£)	276,613
Status	Completed
Type	Research Grant
Start date	19/07/2004
End date	18/07/2007
Duration	36 months

Abstract

We showed recently that ACTH would stimulate fetal testicular steroidogenesis. While confirming a likely link between fetal Leydig cell and adrenocortical cell differentiation, the sensitivity and magnitude of the effect suggests that ACTH may play a role in the normal development of fetal Leydig cell function. Studies outlined in this proposal are designed to characterise this novel endocrine regulatory mechanism. The cellular and molecular effects of ACTH on testis will be determined and comparison will be made of the effects of ACTH and LH on the testis and the effects of ACTH on the adrenal and testis. The role of ACTH on testis function will be determined in mice with increased or decreased circulating levels of LH and/or ACTH.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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