Award details

Bioengineering and tissue engineering of the human cornea

Reference	BBS/B/01162
Principal Investigator / Supervisor	Professor Stephen Rimmer
Co-Investigators / Co-Supervisors	Professor Sheila MacNeil
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	230,530
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

We propose a stepwise approach to the development of a series of permanent hybrid synthetic/biological constructs for future use in corneal reconstruction. We will combine advances in polymer synthesis with recent breakthroughs in the transplantation of cultured corneal and mucosal epithelium to produce a series of biomimetic hydrogel implants with optimum biomechanical and biocompatability properties. These will be modified to facilitate epithelialisation and wound healing but to discourage biofouling and inflammatory reactions. These implants will be designed to either be inserted cell-free and be colonised in vivo by the patients own cells, or alternatively, where the ability of the patients own corneal cells to colonise implants is compromised, we will develop methodology for pre-loading of the implants with autologous mucosal cells. (Joint with BBS/B/01022).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/01022 Bioengineering and tissue engineering of the cornea

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search