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The ability of fatty acids to modulate the inflammatory effects of macrophage/monocytes on endothelial cells

Reference	BBS/B/01057
Principal Investigator / Supervisor	Professor George Rainger
Co-Investigators / Co-Supervisors	Professor Robert Grimble, Professor Gerard Nash
Institution	University of Birmingham
Department	Medical Sciences - Physiology
Funding type	Research
Value (£)	300,164
Status	Completed
Type	Research Grant
Start date	26/04/2004
End date	25/06/2007
Duration	38 months

Abstract

Inflammation is promoted by monocyte/macrophages (M) recruitment to tissue, and this may be particularly relevant in chronic inflammatory disease. Modulators of the inflammatory potential of M may be an individuals intake of specific fatty acids (FA), with N3-polyunsaturated FA (PUFAs) being anti-inflammatory and N-6 PUFAS pro- inflammatory. M will be cultured alone and with endothelial cells (EC) in the presence or absence of different fatty acids. The effect of the FA environment on the inflammatory potential of M will be assessed in a novel coculture based leukocyte adhesion assay. We aim to determine which FAs modulate the ability of M to promote leukocyte adhesion to EC and to investigate the molecular basis of this process.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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