Award details

Bioengineering and tissue engineering of the cornea

Reference	BBS/B/01022
Principal Investigator / Supervisor	Dr Nigel Fullwood
Co-Investigators / Co-Supervisors
Institution	Lancaster University
Department	Biological Sciences
Funding type	Research
Value (£)	195,455
Status	Completed
Type	Research Grant
Start date	09/08/2004
End date	08/06/2008
Duration	46 months

Abstract

We propose a stepwise approach to the development of a series of permanent hybrid synthetic/biological constructs for future use in corneal reconstruction. We will combine advances in polymer synthesis with recent breakthroughs in the transplantation of cultured corneal and mucosal epithelium to produce a series of biomimetic hydrogel implants with optimum biomechanical and biocompatability properties. These will be modified to facilitate epithelialisation and wound healing but to discourage biofouling and inflammatory reactions. These implants will be designed to either be inserted cell-free and be colonised in vivo by the patients own cells, or alternatively, where the ability of the patients own corneal cells to colonise implants is compromised, we will develop methodology for pre-loading of the implants with autologous mucosal cells. (Joint with BBS/B/01162).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Industrial Biotechnology, Regenerative Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/01162 Bioengineering and tissue engineering of the human cornea

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