BBSRC Portfolio Analyser
Award details
Application of nanosensor technology to study early embryo development
Reference
BBS/B/00751
Principal Investigator / Supervisor
Professor Jonathan Aylott
Co-Investigators /
Co-Supervisors
Dr Franchesca Houghton
,
Professor Henry Leese
Institution
University of Nottingham
Department
Sch of Chemistry
Funding type
Research
Value (£)
221,524
Status
Completed
Type
Research Grant
Start date
26/07/2004
End date
25/05/2007
Duration
34 months
Abstract
The project uses nanosensor technology for real-time measurement of metabolites to examine the differentiation of early mammalian embryos. Spherical optical nanosensors (diameter less than 100nm) sensitive to oxygen, glucose and nitric oxide will be produced using a microemulsion polymerisation technique. Nanosensor characterisation will be in terms of dynamic range, sensitivity, reversibility and response time and physically in terms of size and surface charge. The nanosensors will be used to elucidate basic mechanisms in preimplantation development at the single cell level; specifically, the access of oxygen to the centre of the embryo, the maintenance of glucose homeostasis and the role of nitric oxide signalling.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search