Award details

Pestvirus evasion of the intracellular antiviral response to infection

Reference	BBS/B/00689
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors	Dr Penelope Powell
Institution	The Pirbright Institute
Department	Div of Molecular Biology
Funding type	Research
Value (£)	321,430
Status	Completed
Type	Research Grant
Start date	01/12/2004
End date	31/08/2009
Duration	57 months

Abstract

Pestivirus infection and persistence in the foetus resulting in the birth of persistently infected animals is correlated with a failure to activate the innate anti-viral response to infection of the host. Our recent collaborative work linked BVDV infection with the inhibition of a key transcription factor in interferon induction, IRF-3. Our proposed studies will involve the preparation of reagents to study interferon induction for use in cattle and pigs, a detailed dissection of pathway that virus infection of cells normally induces interferon in pestivirus infected cells, which virus polypeptides are involved in the inhibition of interferon production, and the generation of designed engineered virus to study its behaviour in cultured cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00662 Pestivirus evasion of the intracellular antiviral response to infection

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