Award details

Pestivirus evasion of the intracellular antiviral response to infection

Reference	BBS/B/00662
Principal Investigator / Supervisor	Professor Steve Goodbourn
Co-Investigators / Co-Supervisors	Dr John McCauley, Dr Penelope Powell
Institution	St George's University of London
Department	Basic Medical Sciences
Funding type	Research
Value (£)	351,508
Status	Completed
Type	Research Grant
Start date	26/07/2004
End date	25/07/2007
Duration	36 months

Abstract

Pestivirus infection and persistence in the foetus resulting in the birth of persistently infected animals is correlated with a failure to activate the innate anti-viral response to infection of the host. Our recent collaborative work linked BVDV infection with the inhibition of a key transcription factor in interferon induction, IRF-3. Our proposed studies will involve the preparation of reagents to study interferon induction for use in cattle and pigs, a detailed dissection of pathway that virus infection of cells normally induces interferon in pestivirus infected cells, which virus polypeptides are involved in the inhibition of interferon production, and the generation of designed engineered virus to study its behaviour in cultured cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00689 Pestvirus evasion of the intracellular antiviral response to infection

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