Award details

Dynamics selection and pathogenicity in avian influenza: from individual to population

Reference	BBS/B/00522
Principal Investigator / Supervisor	Professor Julia Rose Gog
Co-Investigators / Co-Supervisors	Professor Edward Holmes
Institution	University of Cambridge
Department	Zoology
Funding type	Research
Value (£)	229,610
Status	Completed
Type	Research Grant
Start date	01/02/2006
End date	31/01/2011
Duration	60 months

Abstract

(a) Develop a family of models relating pathogen strain structure to epidemic dynamics in Equine Influenza (EI), spanning levels from within-host to population, based on experimentally quantifying: (i) within-host strain dynamics (by genotyping of longitudinal viral samples); (ii) impact of transmission founder effects on viral genetic diversity. (b) Apply the models to understand the dynamics of EIV phylogeny, notably, drift and co-circulation of strains. (c) Generalise the EI model to explore strain dynamics of other pathogens: (i) rabies; and (ii) Foot and Mouth Disease.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology, Systems Biology
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00093 Dynamics selection and pathogenicity in avian influenza: from individual to population

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