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The mechanisms of virus-induced immunosuppression in poultry - the circovirus chicken anaemia virus as a model system

ReferenceBBS/B/00360
Principal Investigator / Supervisor Professor Elizabeth Glass
Co-Investigators /
Co-Supervisors		 Professor David Burt
Institution The Roslin Institute
DepartmentGenetics and Genomics
Funding typeResearch
Value (£) 64,248
StatusCompleted
TypeResearch Grant
Start date 01/10/2004
End date 30/09/2007
Duration36 months

Abstract

Chicken anaemia virus (CAV) is an immunosuppressive circovirus of increasing prevalence, resulting in economic loss to the poultry industry, and exacerbating the effects of other pathogens. The interactions of CAV with its host will be investigated by profiling the host transcriptome following infection in vitro and in vivo. A collaboration between IAH, QUB and RI will exploit a panel of cytokine reagents developed at IAH and a chicken immune-associated microarray developed at RI together with targeted mutants of the three viral genes to be developed at QUB. A co-infection model with Mareks Disease Virus will investigate how CAV interacts with other pathogens. Structure/function analysis of CAV genes will determine its pathogenic and immunosuppressive mechanisms and as such will develop CAV as a model for circovirus infections in other species, including mammals.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding SchemeX – not Funded via a specific Funding Scheme
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