Award details

Marek's disease virus pathogenesis and disease resistance

Reference	BBS/B/00204
Principal Investigator / Supervisor	Professor Helen Sang
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	Gene Expression and Development
Funding type	Research
Value (£)	137,088
Status	Completed
Type	Research Grant
Start date	01/04/2005
End date	30/04/2008
Duration	37 months

Abstract

Mareks disease (MD) is a highly contagious disease caused by an oncogenic alphaherpesvirus. Control of MD is currently achieved by vaccination with live attenuated vaccines. However, the emergence of more virulent strains of Mareks disease virus (MDV) has indicated that alternative strategies will be required to control this disease in the future. A key objective of this proposal is to identify genes associated with the pathogenesis and latency of MDV infection and to exploit this knowledge to develop disease resistant chickens. The strategy will involve analysing gene function using siRNA technology and generation of chickens expressing siRNA transgenically in order to define gene function during MDV infection. The investigation will focus on known transforming/latency genes such as Meq, as well as characterising genes of unknown function. (Joint with BBS/B/0034 and BBS/B/00174)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00034 Marek's disease virus pathogenesis and disease resistance

BBS/B/00174 Marek's disease virus pathogenesis and disease resistance

BBS/B/00204/2 Marek's disease virus pathogenesis and disease resistance

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