Award details

Defining the avian antiviral type I interferon system

Reference	BBS/B/00115
Principal Investigator / Supervisor	Professor Michael Skinner
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	216,708
Status	Completed
Type	Research Grant
Start date	29/11/2004
End date	28/08/2005
Duration	9 months

Abstract

The aim of the project is to address the gap, in reagents and expertise, that exists between research on avian and mammalian type I IFN antiviral systems. We will define major components of the avian system, identifying both those features in common with the mammalian system but particularly highlighting any significant differences. We will clone components for expression by trawling existing EST database and also be subtractive or functional cloning of IFN-induced mRNAs. We will assay the biochemical or cell signalling activities of selected components. We will investigate the ability of avian viruses to block IFN induction and signalling or to resist IFN-induced antiviral activity, and attempt to identify viral modulators and targets.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00115/2 Defining the avian antiviral type I interferon system

BBS/B/00344 Defining the avian antiviral type I interferon system

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