Award details

Dynamics selection and pathogenicity in avian influenza: from individual to population

Reference	BBS/B/00093
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Molecular Biology
Funding type	Research
Value (£)	329,169
Status	Completed
Type	Research Grant
Start date	14/11/2004
End date	13/11/2009
Duration	60 months

Abstract

Avian influenza poses a serious disease threat to animal and human populations, and provides an unusual opportunity to synthesise ecological and evolutionary pathogen dynamics. We shall use experimental infections, phylogenetics and mathematical modelling to explore the dynamics and evolution of low (LPAI ) and high (HPAI) pathogenicity influenza infections in chickens, based on viral isolates from field outbreaks of HPAI. We shall clarify: (i) the dynamics of LPAI and HPAI infection and host immunity in naive and previously HPAI- infected birds; (ii) evolutionary changes in the viral haemagglutinin molecule which determine the adaptation of LPAI to chickens and its transition to HPAI; (iii) the transmission dynamics of LPAI and HPAI infection at different scales.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology, Microbiology, Systems Biology
Research Priority	X – Research Priority information not available
Research Initiative	Combating Viral Diseases of Livestock Initiative (CVDL) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/00522 Dynamics selection and pathogenicity in avian influenza: from individual to population

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