Award details

Development and integration of a cortisol sensor with real-time read-out to an ambulatory microdialysis sampling system

Reference	BB/T004177/1
Principal Investigator / Supervisor	Professor Stafford Lightman
Co-Investigators / Co-Supervisors	Professor Gianni Angelini, Professor Anthony Cass, Professor Pantelis Georgiou, Dr Ben Gibbison, Professor Chris Rogers
Institution	University of Bristol
Department	Bristol Medical School
Funding type	Research
Value (£)	640,673
Status	Current
Type	Research Grant
Start date	01/06/2020
End date	31/12/2023
Duration	43 months

Abstract

unavailable

Summary

The hormone cortisol is secreted in response to physical and psychological stress and affects most tissues in the body. In health, it is secreted in a circadian rhythm, but when samples are taken frequently enough, an ultradian rhythm of pulses lasting about an hour can be seen. Large amplitude pulses produce the highs and small or no pulses the lows. The body reads these pulses - it is not just the amount of cortisol, but the pattern that affects which genes are activated. Using BBSRC funding, we developed a blood-free device for sampling cortisol. It takes frequent samples that allow us to see the pulses of cortisol. We can attach it to an individual and they go about their life. At the moment, we analyse the samples in a laboratory. We want to develop a sensor for cortisol to fit in the device, so that the results are immediately available. We have identified a molecule that detects cortisol, but need to turn this into a working sensor and integrate this with our collection device.

Committee	Not funded via Committee
Research Topics	Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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