Award details

Development of a Nucleoside Diphosphate Platform for the Chemo-Enzymatic Synthesis of Nucleoside Triphosphates

Reference	BB/T004134/1
Principal Investigator / Supervisor	Professor David Hodgson
Co-Investigators / Co-Supervisors	Professor Ian Baxendale, Professor Martin Cann
Institution	Durham University
Department	Chemistry
Funding type	Research
Value (£)	201,760
Status	Completed
Type	Research Grant
Start date	01/07/2020
End date	05/07/2022
Duration	24 months

Abstract

unavailable

Summary

Nucleoside triphosphates (NTPs) are Nature's raw materials for the assembly of the nucleic acids that store genetic material. We have developed an enzyme-based method that allows us to prepare NTPs. We use inexpensive materials in our processes, however, we are not sure how efficient or broadly-applicable our system is or how it compares to other known enzyme systems. We have gathered independent market research to show that our system could have broad interest to industrialists. Through this consultation, however, it was clear that further information on the breadth of scope and the limitations of our system were required before industry could consider adopting it. Furthermore, we also need to convert our system from something that works in a research laboratory into something that can be employed robustly on a chemical plant. The proposed work aims to broaden our understanding and translate our research towards industrial applications

Committee	Not funded via Committee
Research Topics	Industrial Biotechnology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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