Award details

Re-engineering robustness in to industrial antibiotic producing Streptomyces strains

Reference	BB/T004126/1
Principal Investigator / Supervisor	Professor Paul Hoskisson
Co-Investigators / Co-Supervisors	Dr Iain Hunter
Institution	University of Strathclyde
Department	Inst of Pharmacy and Biomedical Sci
Funding type	Research
Value (£)	348,356
Status	Completed
Type	Research Grant
Start date	01/10/2019
End date	31/08/2022
Duration	35 months

Abstract

unavailable

Summary

Currently around two-thirds of our antibiotics are made by the soil bacterium Streptomyces. Industrial Streptomyces usually undergo several rounds of random mutagenesis to improve their production characteristics becoming highly-adapted to industrial culture conditions. There is a problem, however, highly-adapted strains are less flexible limiting alterations to production processes and the introduction of sustainable feedstocks. This project will identify genes used by the bacteria to adapt to certain feedstocks and develop new, rapid methods to repair genes lost or damaged genes during mutagenesis, maintaining performance and increasing the flexibility of high-producing strains. This is important because the generation of industrial strains is time consuming and labour intensive. Understanding what limits flexibility in high-yielding antibiotic producers and repairing these mutations will make it easier and greener to make future antibiotics and combat antimicrobial resistance.

Committee	Not funded via Committee
Research Topics	Industrial Biotechnology, Microbiology, Synthetic Biology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search