Award details

Next generation peste-des-petits ruminats (PPR) vaccines that differentiate between infected and vaccinated animals (DIVA) - proof of concept in sheep

Reference	BB/T004096/1
Principal Investigator / Supervisor	Dr Tobias Tuthill
Co-Investigators / Co-Supervisors	Professor Satya Parida
Institution	The Pirbright Institute
Department	Vaccine Differentiation
Funding type	Research
Value (£)	158,845
Status	Completed
Type	Research Grant
Start date	01/04/2020
End date	30/09/2021
Duration	18 months

Abstract

unavailable

Summary

Peste des petits ruminants (PPR), is a highly contagious viral disease of sheep and goats in Africa, and Asia. Recent outbreaks in Northern Africa, Bulgaria and European part of Turkey represent a significant threat to mainland of Europe and UK. Although effective live attenuated vaccines are available, the critical drawback of these vaccines and associated tests is their inability to differentiate infection in vaccinated animals (DIVA). Therefore, it is almost impossible to assess the quality and efficacy of existing PPR vaccines without knowing whether positive animals are vaccinated or naturally infected. This slows down the implementation of PPR control through vaccination. In an existing BBSRC grant, we have developed two PPR live attenuated DIVA vaccines and their companion tests. Both of these have already been successfully tested in goats. The aim of this project is to now test these vaccines in sheep to facilitate the licensing and commercialisation by vaccine producers.

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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