Award details

Algae-UK: exploiting the algal treasure trove

Reference	BB/S009825/1
Principal Investigator / Supervisor	Professor Saul Purton
Co-Investigators / Co-Supervisors	Professor Anna Amtmann, Professor Patricia Harvey, Professor Michele Stanley
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	735,476
Status	Current
Type	Research Grant
Start date	01/04/2019
End date	31/03/2024
Duration	60 months

Abstract

Eukaryotic and prokaryotic algae are diverse photosynthetic organisms that have considerable potential as industrial biotechnology (IB) platforms for a wide range of natural and engineered bio-products, from bioplastics and biofuels to high value bioactives. Moreover, cultivation of microalgae or cyanobacterial in closed photobioreactors offers an attractive low-carbon alternative to existing heterotrophic technologies, whereas cultivation of macroalgae (seaweeds) offers an alternative to crop cultivation on arable land. However, algal IB is an immature field that requires step-changing advances in algal biology, genetic engineering, cultivation at scale and downstream processing. Currently, considerable research and development is occurring in countries such as the US and China, and several European countries, as is evident from $m investments and the many start-up companies. The previously funded PHYCONET NIBB (which focussed mainly on microalgae) has brought together academic researchers, a fledgling industrial sector and other key stakeholders to create a vibrant, cohesive community of over 600. PHYCONET has significantly raise the profile and interest in microalgal IB within the UK and helped give this community an international voice. Network support has progressed a number of key projects up the TRL scale and catalysed engagement with the wider community. The new network, Algae-UK, will build on this momentum by broadening the remit of the new network to encompass macroalgae, and to give more focus to the emerging area of cyanobacterial synthetic biology. It will serve as the hub for the UK algal biosciences research community, businesses operating in the IB sector, and other stakeholders - creating the critical mass of expertise, effort and focus needed to achieve key step-changes and make the UK a leading player in algal biotechnology.

Summary

'Algae' are photosynthetic organisms with the term encompasses both macroscopic forms (seaweeds) and microscopic forms (eukaryotic microalgae and cyanobacteria). The unifying features of algae is that they use sunlight to convert CO2 into biomass and they grow in an aquatic environment. There is huge biological diversity amongst the 100,000's species of algae with many suitable as sources of food, livestock and aquaculture feed, natural fibres and biofuels. In addition, compounds derived from algae have a wide range of potential applications such as novel drugs, health supplements, bio-polymers and natural pigments. Algae therefore represent an important component of a sustainable, bio-based future in which valuable products are generated from CO2 and basic nutrients by photosynthesis, but cultivation does not require arable land, unlike crop plants. Furthermore, advances in genetic engineering and synthetic biology offer the possibility of designer cyanobacteria or microalgae tailored to produce a range of novel high-value recombinants such as therapeutic proteins and speciality biomolecules. The UK has an excellent science base in the biology and biotechnology of cyanobacteria, microalgae and macroalgae. However, it remains small and relatively under-resourced compared to the millions of dollars being invested in applied algal research in the US, China, and in mainland Europe. Despite this, the current PHYCONET NIBB has built an enthusiastic community of academics, industry and other stakeholders and helped catalyse significant R&D and engagement in the area of 'high value products from microalgae'. The new network, Algae-UK, will build on this momentum by broadening the remit of the network to encompass macroalgae, and to give more focus to the emerging area of cyanobacterial synthetic biology. Furthermore, Algae-UK will extend its focus beyond high-value products: this is particularly relevant for macroalgae where the last few years has seen a dramatic increasein interest in seaweeds as health foods and dietary supplements, as well as animal feeds, fertilisers and sources of hydocolloid polymers used as natural thickeners and gums. The objectives of Algae-UK will be to support translational research into key areas that are likely to advance the algal biotechnology sector. Namely: i) genetic improvement and domestication of key algal species; ii) development of advanced platform strains through applications of synthetic biology; iii) exploitation of algal metabolic diversity; iv) advancing engineering solutions to efficient cultivation and downstream processing; v) understanding the opportunities and barriers to commercial success, including regulation, environmental constraints; public acceptance; market competition. Algal-UK will serve as the hub for the UK algal biosciences research community, businesses operating in the IB sector, and other stakeholders - creating the critical mass of expertise, effort and focus needed to achieve the step-change and make the UK a leading player in algal biotechnology. We will also forge links with other algal biotech networks and organizations in Europe, the US, China and other leading countries to further raise the profile of the UK community and share funding and training opportunities.

Impact Summary

There is considerable interest in the UK and indeed worldwide in developing an algal industrial biotechnology (IB) sector, both at the level of policy makers and research funders, but also industry. However, because exploitation is still at an early stage, there needs to be some form of proven platform technology before industry would feel confident about moving into the area. Through the Algae-UK network we to aim to tackle this issue head on, by creating the critical mass of expertise, effort and focus needed to achieve the step-change and make the UK a leading player in algal biotechnology. This will benefit a wide range of IB sectors that have interest in natural bio-products, including the pharmaceuticals, nutraceuticals, cosmetics, food, feed and biofuel industries. Government and Public Bodies will also benefit, since the outputs of the network can have an impact on several pressing current issues: building the knowledge economy will lead to inward investment and wealth creation, and contribute to sustainable economic growth, improve security of food and materials, and contribute to enhanced nutrition. The outreach activities aim to increase awareness of the public on issues of natural products and the bio-based economy, energy, food and material security, and how the development of IB and a knowledge economy can benefit the UK. This will encourage pupils to adopt a career in science and technology, and policy makers to promote research investment into the algal IB sector.

Committee	Not funded via Committee
Research Topics	Industrial Biotechnology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Networks in Industrial Biotechnology and Bioenergy (NIBB) [2013]
Funding Scheme	X – not Funded via a specific Funding Scheme

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