Award details

Development, production and testing of novel glycoconjugate pig vaccines

Reference	BB/S004963/1
Principal Investigator / Supervisor	Professor Brendan Wren
Co-Investigators / Co-Supervisors	Dr Jon Cuccui
Institution	London Sch of Hygiene and Trop Medicine
Department	Department of Pathogen Molecular Biology
Funding type	Research
Value (£)	557,778
Status	Completed
Type	Research Grant
Start date	01/04/2019
End date	31/03/2021
Duration	24 months

Abstract

unavailable

Summary

Healthily maintained livestock are essential for economic and societal prosperity. We propose to exploit ground-breaking technology to produce low cost glycoconjugate vaccines to protect against three major pig diseases (porcine pleuropneumonia, Glässer's disease and S. suis-induced meningitis), where current vaccines are unsatisfactory. We have developed technology to generate cloned glycoconjugates in E. coli cells that act as mini factories to produce an inexhaustible and renewal supply of pure vaccine. Due to production costs, conventional chemically synthesised glycoconjugate vaccines have not been used for animals, but have an excellent track record in humans, where over a billion doses have been used. Through the LSHTM business development office and industrial collaborators we will develop, produce and test new vaccines against the three major pig respiratory diseases. A new company, ArcVax, will be spun-out to further develop the technology and commercialise vaccine product.

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Industrial Biotechnology, Microbiology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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