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Unlocking high-throughput analysis within the RNA epigenetics domain

Reference	BB/S004947/1
Principal Investigator / Supervisor	Professor Anastasia Callaghan
Co-Investigators / Co-Supervisors
Institution	University of Portsmouth
Department	Inst of Biomedical and Biomolecular Sc
Funding type	Research
Value (£)	202,097
Status	Completed
Type	Research Grant
Start date	01/04/2019
End date	30/09/2021
Duration	30 months

Abstract

unavailable

Summary

In the rapidly emerging field of RNA epigenetics, reversible chemical modifications of RNA by writer, reader and eraser proteins are known to play key roles in changing RNA activity and regulating critical cellular processes. Mass spectrometry and sequencing techniques are used to detect RNA modifications, but neither are capable of high-throughput analysis. To support the exponential growth of research in this field there is an urgent need for high-throughput approaches. Working with RNA epigenetics experts, Storm Therapeutics, this goal can be achieved by repurposing our patented RNA array platform technology to facilitate simultaneous analysis of multiple target RNAs for RNA modification detection. With market exclusivity, the tailoring of our RNA array into the RNA epigenetics domain offers a very significant increase in its utility, greatly increasing its market potential and substantially enhancing its attractiveness to potential licensees.

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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