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Further development of infectious bronchitis virus vaccines adapted for production in cell culture
Reference
BB/R019576/1
Principal Investigator / Supervisor
Dr Erica Bickerton
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Coronaviruses
Funding type
Research
Value (£)
262,701
Status
Completed
Type
Research Grant
Start date
23/10/2018
End date
22/04/2020
Duration
18 months
Abstract
unavailable
Summary
Infectious bronchitis virus (IBV) causes a respiratory disease in chickens making them more susceptible to bacterial infections. Chickens infected with IBV gain less weight and produce fewer high quality eggs. It is important to vaccinate against IBV both for welfare and economic reasons. Many fertilised chicken eggs are used to produce vaccines against IBV. Egg-based vaccine production has numerous disadvantages. We have identified a method to produce live vaccines on a cell line which is beneficial to the vaccine industry as well as the poultry industry, reducing the number of eggs utilised in vaccine production; an important consideration under the principles of the 3Rs. Vaccine production on cell lines is faster and more efficient than on eggs and large volumes of vaccine can be produced. We aim to further develop this method to generate vaccines against IBV that can be produced in cell culture and to license these products to a commercial partner.
Committee
Not funded via Committee
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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