Award details

MAGMA

Reference	BB/R005516/1
Principal Investigator / Supervisor	Professor Andrew Baldwin
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Oxford Chemistry
Funding type	Research
Value (£)	131,870
Status	Completed
Type	Research Grant
Start date	01/12/2017
End date	30/11/2018
Duration	12 months

Abstract

unavailable

Summary

NMR is an important tool in drug discovery. Its use is rising in industry owing to its applicability notably to disordered, and membrane proteins that are of significant interest, but are not amenable to crystallography. Widespread use of NMR has been limited by its complexity, and the size of molecules it can be applied to. We have developed MAGMA, a novel analytical approach that facilitates the study of 'large', >30KDa, proteins in structure-function research, applicable to the majority of targets of interest to the biopharmaceutical industry. Our approach relates features in NMR spectra to specific atoms in the molecule, taking a process that could take several labour-intensive months with costly samples down to a single sample and a few hours. To realise the commercial potential, this project will allow us to refine the MAGMA software that can be used by a non-specialist. We seek to license this robust software platform for use in academic research, and commercial drug discovery.

Committee	Not funded via Committee
Research Topics	Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search