Award details

Improved conjugate vaccines derived from a bacterial immunomodulatory protein

Reference	BB/N022165/1
Principal Investigator / Supervisor	Professor Jean van den Elsen
Co-Investigators / Co-Supervisors	Professor Kevin Marchbank
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	191,107
Status	Completed
Type	Research Grant
Start date	10/10/2016
End date	09/07/2018
Duration	21 months

Abstract

unavailable

Summary

TB remains a major health and economic burden. Key discoveries (University of Bath) and initial vaccination studies (Newcastle University) have established that a bacterial protein known as Sbi (from Staphylococcus aureus) can improve immune responses to a TB fragment. What makes our Sbi pro-vaccines an attractive commercial opportunity is our findings that Sbi can locally activate the innate immune system of all mammals tested to date. As such, vaccines developed using Sbi could be used across multiple species, including cattle and humans. Here, we will establish how successful Sbi conjugates/compounds are at generating an appropriate adaptive immune response against TB. These studies will lead to full TB challenge experiments in the future, which will allow us to confirm Sbi conjugates as highly effective multifunctional vaccines for animals; providing a clear pathway to commercialization of novel Sbi conjugate based vaccines to improve animal health and world food security.

Committee	Not funded via Committee
Research Topics	Immunology, Microbiology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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